IMIDAZO 1 2 A PYRIDINE DOWNLOAD

Imidazo[1,2-a]pyridine—an example of imidazopyridine and a core structure of zolpidem and some compounds described below. The imidazopyridines are a class of drugs defined by their chemical structure. In general, they. Imidazo(1,2-A)pyridine | C7H6N2 | CID - structure, chemical names, physical and chemical properties, classification, patents, literature, biological  Molecular Formula‎: ‎C7H6N2. Diversity-oriented synthesis of the biologically intriguing imidazo[1,2-a]pyridine-fused isoquinoline systems from readily available starting.


IMIDAZO 1 2 A PYRIDINE DOWNLOAD

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IMIDAZO 1 2 A PYRIDINE DOWNLOAD


Reproduced material should be attributed as follows: For reproduction of material from NJC: For reproduction of material from PCCP: For reproduction of material from PPS: Jump to Figure 1 Multicomponent reactions MCRs []comprising three or more components, provide straightforward approaches to a wide range of heterocycles through imidazo 1 2 a pyridine formation of various bonds in a one-pot process.

These reactions not only greatly accelerate chemical syntheses [20]but also allow access to diverse chemical structures [21] from readily accessible building blocks.

In the past decades, considerable efforts have been made towards the development of new MCRs and imidazo 1 2 a pyridine application to the diversity-oriented synthesis of biologically relevant molecules for drug discovery [].

The Ugi reaction [28]an imidazo 1 2 a pyridine pioneer of a multicomponent reaction, represents a powerful synthetic tool to assemble versatile peptide-like compounds. It has found many applications in the facile synthesis of natural products and biologically interesting molecules [29,30].

Accordingly, the combination of the Ugi reaction with other transformations proved to be powerful strategies for the efficient synthesis of novel heterocycles.

IMIDAZO 1 2 A PYRIDINE DOWNLOAD

Due to the atom and step economy, high efficiency and intriguing biological profiles of the products, the GBB reaction has attracted broad imidazo 1 2 a pyridine in the field of organic synthesis [].

In order to expand the structural diversity of GBB products, further investigation of GBB-based synthetic strategies remains highly desirable. Bijanzadeh, Synlett, A facile formation of C-N, C-O, and C-S bonds from ynals, pyridinamines, and alcohols or thiols enables a transition-metal-free three-component reaction for the construction of imidazo[1,2-a]pyridines.

These one-pot reactions proceed smoothly with commercially available catalysts and afford the products in good yields. A practical intramolecular C-H functionalization reaction of N-aryl enamines with molecular iodine as the sole oxidant in the presence of copper iodide CuI provides diverse imidazo[1,2-a]pyridine and indole derivatives via I2-mediated oxidative C-N and C-C bond formation, respectively.

IMIDAZO 1 2 A PYRIDINE DOWNLOAD

This reaction also works well with crude enamines. Reactions carried out under microwave irradiation give the highest yields of products in reaction times of less than two minutes.

IMIDAZO 1 2 A PYRIDINE DOWNLOAD

Adimurthy, Synthesis, An efficient microwave-assisted metal-free amino benzannulation of aryl 4-aryl propynyl -1H-imidazolyl methanone with dialkylamines affords various 2,8-diarylaminoimidazo[1,2-a]pyridines in good yield.

Bhuvanesh, Synlett,23, Huang, Synthesis,48, Li, Synlett,

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